{"id":3488,"date":"2026-04-20T18:31:41","date_gmt":"2026-04-20T18:31:41","guid":{"rendered":"https:\/\/news.psva.org\/?p=3488"},"modified":"2026-04-22T17:50:00","modified_gmt":"2026-04-22T17:50:00","slug":"a-complicated-case-of-connections-between-mental-illness-and-treatment","status":"publish","type":"post","link":"https:\/\/news.psva.org\/?p=3488","title":{"rendered":"A Complicated Case of Connections Between Mental Illness and Treatment"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>By Anita Kablinger, MD, CPI, DFAAP, DLFAPA, FACRP, FASCP<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This presentation explored the complex interplay between neuromodulation treatments and mood disorder diagnosis through a detailed clinical case. A 46-year-old man with long-standing treatment resistant depression experienced significant improvement following vagus nerve stimulation (VNS), only to later develop a first-ever manic episode several months into treatment. The episode prompted hospitalization, adjustment of stimulation parameters, and initiation of mood stabilizers, ultimately leading to a revised diagnosis of Bipolar I Disorder. With careful management, the patient was able to safely continue VNS and demonstrated sustained improvement in depressive symptoms over long-term followup.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The case highlights both the therapeutic potential and diagnostic implications of neuromodulation in mood disorders. While treatments such as ECT, rTMS, and VNS offer meaningful benefits for patients with refractory depression, they can occasionally unmask underlying bipolarity, particularly in individuals with risk factors such as family history or substance use disorders. The key message emphasized the importance of thorough screening, vigilant monitoring for emergent manic symptoms, and timely intervention. When managed appropriately, neuromodulation remains a safe and effective option\u2014even after treatment-emergent mania\u2014underscoring its valuable role in contemporary psychiatric care.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>By Anita Kablinger, MD, CPI, DFAAP, DLFAPA, FACRP, FASCP This presentation explored the complex interplay between neuromodulation treatments and mood disorder diagnosis through a detailed clinical case. A 46-year-old man with long-standing treatment resistant depression experienced significant improvement following vagus nerve stimulation (VNS), only to later develop a first-ever manic episode several months into treatment. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[80],"class_list":["post-3488","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-spring-2026"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v16.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Complicated Case of Connections Between Mental Illness and Treatment - PSV News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.psva.org\/?p=3488\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Complicated Case of Connections Between Mental Illness and Treatment - PSV News\" \/>\n<meta property=\"og:description\" content=\"By Anita Kablinger, MD, CPI, DFAAP, DLFAPA, FACRP, FASCP This presentation explored the complex interplay between neuromodulation treatments and mood disorder diagnosis through a detailed clinical case. A 46-year-old man with long-standing treatment resistant depression experienced significant improvement following vagus nerve stimulation (VNS), only to later develop a first-ever manic episode several months into treatment. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/news.psva.org\/?p=3488\" \/>\n<meta property=\"og:site_name\" content=\"PSV News\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-20T18:31:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-22T17:50:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ray Hall\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/news.psva.org\/#website\",\"url\":\"https:\/\/news.psva.org\/\",\"name\":\"PSV News\",\"description\":\"Psychiatric Society of Virginia Newsletters\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/news.psva.org\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/news.psva.org\/?p=3488#webpage\",\"url\":\"https:\/\/news.psva.org\/?p=3488\",\"name\":\"A Complicated Case of Connections Between Mental Illness and Treatment - PSV News\",\"isPartOf\":{\"@id\":\"https:\/\/news.psva.org\/#website\"},\"datePublished\":\"2026-04-20T18:31:41+00:00\",\"dateModified\":\"2026-04-22T17:50:00+00:00\",\"author\":{\"@id\":\"https:\/\/news.psva.org\/#\/schema\/person\/b3ff623305ba59e337e22c31c9fc42e7\"},\"breadcrumb\":{\"@id\":\"https:\/\/news.psva.org\/?p=3488#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/news.psva.org\/?p=3488\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/news.psva.org\/?p=3488#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/news.psva.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A Complicated Case of Connections Between Mental Illness and Treatment\"}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/news.psva.org\/#\/schema\/person\/b3ff623305ba59e337e22c31c9fc42e7\",\"name\":\"Ray Hall\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/news.psva.org\/#personlogo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/77c2e3f00618d6950c250a915344c15d9f601fb38bd861cae3882e3489cd7d18?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/77c2e3f00618d6950c250a915344c15d9f601fb38bd861cae3882e3489cd7d18?s=96&d=mm&r=g\",\"caption\":\"Ray Hall\"},\"url\":\"https:\/\/news.psva.org\/?author=3\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A Complicated Case of Connections Between Mental Illness and Treatment - PSV News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/news.psva.org\/?p=3488","og_locale":"en_US","og_type":"article","og_title":"A Complicated Case of Connections Between Mental Illness and Treatment - PSV News","og_description":"By Anita Kablinger, MD, CPI, DFAAP, DLFAPA, FACRP, FASCP This presentation explored the complex interplay between neuromodulation treatments and mood disorder diagnosis through a detailed clinical case. A 46-year-old man with long-standing treatment resistant depression experienced significant improvement following vagus nerve stimulation (VNS), only to later develop a first-ever manic episode several months into treatment. [&hellip;]","og_url":"https:\/\/news.psva.org\/?p=3488","og_site_name":"PSV News","article_published_time":"2026-04-20T18:31:41+00:00","article_modified_time":"2026-04-22T17:50:00+00:00","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Ray Hall","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebSite","@id":"https:\/\/news.psva.org\/#website","url":"https:\/\/news.psva.org\/","name":"PSV News","description":"Psychiatric Society of Virginia Newsletters","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/news.psva.org\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/news.psva.org\/?p=3488#webpage","url":"https:\/\/news.psva.org\/?p=3488","name":"A Complicated Case of Connections Between Mental Illness and Treatment - PSV News","isPartOf":{"@id":"https:\/\/news.psva.org\/#website"},"datePublished":"2026-04-20T18:31:41+00:00","dateModified":"2026-04-22T17:50:00+00:00","author":{"@id":"https:\/\/news.psva.org\/#\/schema\/person\/b3ff623305ba59e337e22c31c9fc42e7"},"breadcrumb":{"@id":"https:\/\/news.psva.org\/?p=3488#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/news.psva.org\/?p=3488"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/news.psva.org\/?p=3488#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/news.psva.org\/"},{"@type":"ListItem","position":2,"name":"A Complicated Case of Connections Between Mental Illness and Treatment"}]},{"@type":"Person","@id":"https:\/\/news.psva.org\/#\/schema\/person\/b3ff623305ba59e337e22c31c9fc42e7","name":"Ray Hall","image":{"@type":"ImageObject","@id":"https:\/\/news.psva.org\/#personlogo","inLanguage":"en-US","url":"https:\/\/secure.gravatar.com\/avatar\/77c2e3f00618d6950c250a915344c15d9f601fb38bd861cae3882e3489cd7d18?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/77c2e3f00618d6950c250a915344c15d9f601fb38bd861cae3882e3489cd7d18?s=96&d=mm&r=g","caption":"Ray Hall"},"url":"https:\/\/news.psva.org\/?author=3"}]}},"featured_image_src":null,"featured_image_src_square":null,"author_info":{"display_name":"Ray Hall","author_link":"https:\/\/news.psva.org\/?author=3"},"_links":{"self":[{"href":"https:\/\/news.psva.org\/index.php?rest_route=\/wp\/v2\/posts\/3488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/news.psva.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.psva.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.psva.org\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/news.psva.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3488"}],"version-history":[{"count":0,"href":"https:\/\/news.psva.org\/index.php?rest_route=\/wp\/v2\/posts\/3488\/revisions"}],"wp:attachment":[{"href":"https:\/\/news.psva.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.psva.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.psva.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}